Hamish had the ____________ to lose his job only three weeks after getting married.

The correct answer is "misfortune." In this context, the word "misfortune" specifically refers to an unfortunate event or situation, which aligns well with the implication that losing a job shortly after getting married is a negative circumstance. The prefix "mis-" conveys the idea of bad luck or adversity, making "misfortune" the most suitable choice here.

"Luck" and "fortune" generally convey positive connotations, often associated with good luck or favorable circumstances, which does not apply in this case. "Chance," while related to possibility or opportunity, does not carry the same negative weight that "misfortune" does in this specific context. Using "misfortune" accurately captures the severity of the situation and highlights that it is an undesirable outcome.